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Both produce large average weight loss in obesity

Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1

These chemicals are degraded by gut microbial enzymes (choline-TMA lyases) into trimethylamine (TMA), which subsequently enters the portal circulation and is oxidized in the liver by flavin-containing monooxygenases (FMOs) to produce TMAO (158)

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The theory is that gradual dose reduction gives the body time to recalibrate appetite and metabolic signaling, rather than experiencing a sudden return to pre-treatment hunger levels